Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions

Molecular pathological epidemiology of colorectal cancer in Chinese patients with KRAS and BRAF mutations

An investigation of interactive effects of exogenous and endogenous factors and tumor molecular changes can lead to a better understanding of tumor molecular signatures in colorectal cancer. We here report a molecular pathological epidemiology study in a large cohort of 945 colorectal cancer patients. Mutations of KRAS (36.6%) and BRAF (3.46%) were nearly mutually exclusive. KRAS-mutated tumors...

Lifestyle factors and microsatellite instability in colorectal cancer: the evolving field of molecular pathological epidemiology.

Colorectal cancer is not a single disease. It encompasses heterogeneous diseases with different sets of genetic and epigenetic alterations. Each tumor arises and behaves in a unique fashion that is unlikely to be exactly recapitulated by any other tumor (1). Nevertheless, we classify colorectal cancers into a limited number of groups (eg, microsatellite instability [MSI]-high vs microsatellite ...

molecular and physiological characterizations of floral scent production in rosa damascena mill.

گل محمدی (r. damascena mill.)مهمترین گونه ای است که در تولید گلاب، عطر و اسانس، در صنعت عطرسازی و دارویی کاربرد دارد. با وجود اهمیت عطر گل محمدی، پژوهش های مولکولی و بیوشیمیایی عطر گل این گونه هنوز در مراحل ابتدایی است. در این پژوهش، ویژگی های مولکولی و فیزیولوژیکی تولید عطر در گل محمدی در آزمایش های مختلف مورد بررسی قرار گرفتند. در آزمایش اول، پژوهشی به منظور بررسی تنوع شیمیایی اسانس میان 44 ت...

Molecular Epidemiology of Colorectal Cancer

The molecular mosaic of the premalignant cutaneous lesions.

In the last three decades, the premalignant cutaneous lesions have represented a milestone for the clinicians and the anatomopathologists given the increased risk of malignant transformation not only in the old but also in the young population. Recent research indicates the fact that, though multiple progresses were recorded in the diagnosis and treatment of the cutaneous squamocellular carcino...